Results from the McLean Study of Adult Development, conducted by Zanarini and colleagues, show that at 16 years of follow-up, 36% of patients with borderline personality disorder take three or more medications, 19% take four or more medications and 7% take five or more medications, Hong said.
“So do [these medications] work? The most we can say is that their efficacy is non-specific. Most clinical trials demonstrate a high placebo success rate and a high dropout rate. The trials are typically short and there are no continuation studies, which limits our ability to interpret much from the results,” Hong told Healio.com/Psychiatry. “Borderline personality disorder is a disorder that has chronic, long-standing symptoms, so trials with shorter time frames can’t tell us much about longer-term results. Furthermore, patients with borderline personality disorder tend to be quite sensitive to side effects.” While there are no FDA-approved medications for personality disorder… –U.S. Psychiatric and Mental Health Congress,Psychiatric Annals, September 15, 2015